This is a "Manhattan" plot -- so named because of how the groupings of dots look like skyscrapers on the Manhattan skyline. This plot is based on a small sample of children (less than 200) who took part in our study and is for illustration purposes only.
This plot shows differences between the extreme high and extreme low groups for genetic variants across the human genome. Each dot represents the results of a statistical test run for a specific genetic variant.
On the X (horizontal) axis of this plot are locations of chromosomes across the human genome (22 chromosome pairs, plus sex-determining pairs). The differences between the high and low groups can be found on the Y (vertical) axis which displays how significant, or meaningful, these differences are according to our statistical analyses. The higher the value, the stronger the genetic association. If the result lies above the dotted line, it is considered statistically significant after accounting for all of the many tests that have been performed.
The power, or strength, of our statistical analyses will be much greater once we have finished data collection and we have a full sample. We anticipate that multiple results will cross the dotted line, or be significant!
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